In case of the transporter-mediated prodrug approach, the rational design of prodrugs should take into account the functional expression and structural requirements for substrate binding and translocation via the transporter, as well as capability to be bioconverted by an enzyme at the target site (74)
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Propionyl-L-carnitine is used for treating leg pain (intermittent claudication) due to poor blood circulation (peripheral vascular disease, PVD)
Samples analysed are from Fig
Bromelain, when taken orally, is absorbed through the gastro-intestinal tract, with up to 40% absorption