All mentioned medications are available by prescription only.
During the last 2 weeks of the titration periods in those 12 participants, semaglutide led to a higher time in range by 4.3 percentage points (5.5, P = 0.02), lower insulin usage by 12.2 U [16.2, 5.4] ( P = 0.008) and lower carbohydrate intake by 50 g (35
Frssing, S., et al., 2018
In that study, tirzepatide was associated with greater average weight loss: People taking the highest dose lost an average of 20.2% of their body weight, compared with 13.7% for those taking semaglutide
Additionally, GLP-1 receptor signaling has been studied in relation to fluid and sodium regulation in the body, though the full mechanisms are still being investigated