These include: Nausea (very common, affecting up to 20% of patients) Diarrhoea (very common) Vomiting (common) Abdominal pain (common) Constipation (common) Dyspepsia (common) These gastrointestinal effects typically emerge during treatment initiation or dose escalation and often diminish over time as the body adapts to the medication
Whether its due to side effect intolerance or having reached the maximum dose, you need a plan of action
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The notion that reduced GLP-1 concentrations would result in a reduction of the prokinetic actions of GLP-1 in the colon (27), causing constipation and abdominal pain, was further supported by the correlation between this and the intensity of abdominal discomfort (28)
Other approaches to muscle anabolic therapeutics share similarities with MSTN inhibition but yield varied results