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Oxidative stress caused by physical/emotional stress, strenuous exercise, exposure to environmental toxins, and immune stress can all cause an increase in free radicals, which may cause oxidative stress and deplete glutathione

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Gluten can worsen it by triggering histamine release and lowering DAO levels especially, in people with celiac or gluten sensitivity

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Clozapine is considered the most effective antipsychotic for treating schizophrenia, with a success rate of approximately 30% in controlling episodes in patients resistant to other treatments, compared to only 4% for the combination of chlorpromazine and benztropine