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Drug-based and surgical approaches should be considered solely as adjunctive measures supplementing this fundamental approach ( When lifestyle interventions prove insufficient, pharmacotherapy and metabolic/bariatric surgery (MBS) merit consideration

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As a homologous enzyme of ACE, ACE2 is found in the hippocampus and cerebral cortex that cleaves Ang II to produce Ang-(17), which activates the Mas receptor and produces an inverse regulation of the ACE/Ang II/AT1 pathway ( 3 The relationship between RAS and depression/anxiety In addition to the systemic RAS, all the components of the RAS independently exist in the brain involving the pathophysiology of depression and anxiety