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Liraglutide administration prevented the decrease of AKT and GSK-3 phosphorylation after treated A 1-42 protein, which inhibiting tau hyperphosphorylation (164, 211)
Marquez-Meneses JD, Olaya-Bonilla SA, Barrera-Carreo S, Tibaduiza-Arvalo LC, Forero-Crdenas S, Carrillo-Vaca L, Rojas-Rodrguez LC, Calderon-Ospina CA, Rodrguez-Quintana J (2025) GLP-1 Analogues in the Neurobiology of Addiction: Translational Insights and Therapeutic Perspectives
Specialist input should always be sought if there are any concerns with drug tolerability
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GLP-1 (glucagon-like peptide-1) receptor agonists, such as Semaglutide , are a class of medications originally developed for the treatment of type 2 diabetes but have also gained recognition for their role in weight management
Continuous GLP-1RA use for three years was associated with the greatest reduction in MACE risk compared with sulfonylureas, whereas interruptions and discontinuations were associated with a progressive attenuation of this protective effect, with risk estimates in some scenarios approaching those of the comparator group
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