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Some obesity medicine specialists suggest higher intakes for specific populations, particularly patients who are physically active, older adults at higher risk for sarcopenia, or those losing weight rapidly

Emanuel, Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity

For people with normal homocysteine levels (e.g., between 7-8), adding folic acid doesnt statistically lower their homocysteine levels.[ref] When researchers compared adding more folate-rich foods (+350 mcg/day of folate) with a folic acid supplement (250 mcg/day of folic acid), they found that both groups had similar decreases in homocysteine.[ref] Who will this work best for

In conclusion, both SGLT2-i and GLP1-RA seem to have several effects on RAAS, though additional studies are needed to clarify this relationship

The main limitation is absorption