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This is the same mechanism that makes GLP-1 agonists like semaglutide effective for weight management

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A 2025 UCSF open-label pilot in Parkinsons disease, the first test of a psychedelic in a neurodegenerative disease, found that two sessions improved mood, cognition, and motor symptoms for weeks to months, with a larger randomized trial now under way

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In addition, in a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity, without affecting centrally regulated anxiety-like behaviors [56]