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Impaired function of HtrA2 leads to compromised mitochondrial function and increased lactate production [61]

Comparative clinical trials directly examining Ipamorelin versus earlier GHRPs have documented the improved selectivity profile

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However, the isolation of antioxidant enzymes in their native form is a very cumbersome and cost-intensive approach, apart from other limitations such as potential immunological problems which can arise during their systemic application as therapeutic agents [69]