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Recently, GPx4 was predicted to be a specific target for new pharmacological therapies aimed at activating or inhibiting cell death in cancer or degenerative diseases [110]

Proc Natl Acad Sci U S A 114(23):E4582E91

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According to different reaction mechanisms, the representative bioorthogonal reactions that have been developed include Staudinger ligation, copper-catalyzed azide-alkyne cycloaddition, and inverse electron-demand Diels-Alder reactions

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