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Because this article has 11 major sections, scan the headings first and then use the FAQ or summary sections to pressure-test the answer
2021;75:e14771
Similarly, if I draw now what a nucleus would like in a cell, when our DNA is very young our cells function perfectly, essentially perfectly because the genes that should be on in a particular cell type, lets say the RGCs at the back of the eye in the optic nerve, they know that theyre nerves because the gene for being a nerve is switched on, but unfortunately what we see is that over time these genes get switched off, and vice versa
Therefore, whether the p21GPX4 axis is a universally present protective mechanism in OA still awaits broader data support (Figure 1)
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